DOE national labs harness AI and supercomputing to advance science, energy and national security—accelerating discoveries in materials, medicine, and beyond.
Argonne National Laboratory
Leveraging world-class expertise and computing power to develop and deploy AI. Our researchers are applying cutting-edge AI systems and agentic models to engineer next-generation materials, fortify the nation’s energy infrastructure, speed breakthroughs in medical treatments, and automate scientific experiments. These efforts are unlocking new frontiers of discovery while enhancing resilience and competitiveness across critical sectors. Learn more about AI at Argonne.
Lawrence Livermore National Laboratory
Lawrence Livermore National Laboratory (LLNL) is harnessing the combined strengths of artificial intelligence (AI) and high-performance computing to accelerate scientific discovery and address complex national security challenges. By integrating advanced AI algorithms with some of the world’s most powerful supercomputers, LLNL is able to analyze massive datasets, optimize simulations, explore complex optimization spaces, and uncover insights that would be impossible with traditional methods. These capabilities support a wide range of mission spaces, including stockpile stewardship, inertial confinement fusion, bioresilience, climate modeling, biomedical research, and advanced manufacturing, enabling LLNL to deliver innovative solutions and maintain its leadership in science and technology. Learn more about AI at LLNL.
National Energy Technology Laboratory
AI-powered approach to precisely identify critical minerals, including rare earth elements, from abandoned Appalachian coal mine drainage with over 90% accuracy. This significantly cuts assessment costs and time. By integrating advanced modeling with biological insights, we offer a scalable, sustainable solution for domestic critical mineral supply, bolstering national resource security.
- Geological Society of America – Abstract
- Computational prospecting for rare earth element feedstocks in Pennsylvania — ACS Fall 2025 — American Chemical Society
Oak Ridge National Laboratory
Oak Ridge National Laboratory first began researching artificial intelligence in 1979 and has since established itself as a global leader in the field through its pioneering AI research that accelerates scientific discovery and supports national priorities in energy, security and innovation. Through ORNL’s Frontier supercomputer, the first to break the exascale barrier at its inception in 2022, laboratory researchers have used AI to tackle some of science’s most pressing problems, earning users numerous Association of Computing Machinery’s (ACM) Gordon Bell awards. The lab is set to continue as a global leader in advancing AI through President Trump’s executive order prioritizing federal investment in AI through initiatives like the ORNL-led American Science Cloud and new systems like the next-generation AI-focused supercomputer Lux, which is set for deployment at ORNL in early 2026. Learn more about AI research at ORNL.
Pacific Northwest National Laboratory
The Center for AI @PNNL is driving a research agenda that explores the foundations and emerging frontiers of AI, combining capability development and application to mission areas in science, security and energy resilience. The Center includes pillars in fundamental research, applied and trustworthy AI to operations, and access to workforce development and world-class infrastructure (to include state-of-the-art AI models, data, and hardware). Learn more about AI research at PNNL.